HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(6-phenyl-5-(trifluoromethyl)pyridin-3-yl)acetamide → HCID 58415894, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(6-phenyl-5-(trifluoromethyl)pyridin-3-yl)acetamide | HCID 67395105 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 58415894 | HCID 58415894 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
To a solution of N-(6-phenyl-5-(trifluoromethyl)pyridin-3-yl)acetamide (1.68 mmol, 0.280 g) in ethanol (6 ml), 2N aqueous NaOH (5 ml) was added. The mixture was heated at 110° C. for 3 hours. The solvent was removed, the pH was set at 8 and extracted with CHCl3. The solvent was removed to afford 0.394 g (98% of yield) of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536165B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-29505630d48342969042ce39b02f1f8e |
| Source note | uspto-grants-2013_09 |