HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 419770Generated: October 31, 2026
Pyridine → (S)-benzyl 2-(2-bromophenylcarbamoyl)-2-methylpyrrolidine-1-carboxylate
https://huagongshe.com/reaction/419770
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-Bromoaniline | HCID 11992 | — |
| Reactant | (S)-benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate | HCID 86643491 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | (S)-benzyl 2-(2-bromophenylcarbamoyl)-2-methylpyrrolidine-1-carboxylate | HCID 86643492 | — |
Reaction Steps
To a solution of EXAMPLE 5A in toluene (20 mL) and N,N-dimethylformamide (10 mL) was added 2-bromoaniline (0.891 g) and pyridine (1.38 mL) and the mixture heated at 40° C. for 4 hours. The mixture was treated with ethyl acetate and brine and the organic layer was washed with 5% aqueous citric acid and aqueous sodium bicarbonate, dried over magnesium sulfate, and concentrated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08093396B2 |
|---|
| Source dataset | uspto-grants-2012_01 |
|---|
| ORD ID | ord-4eaec1b767ef4e608c986dd8e82c3314 |
|---|
| Source note | uspto-grants-2012_01 |
|---|
