反应详情

温度

40 °C

To a solution of EXAMPLE 5A in toluene (20 mL) and N,N-dimethylformamide (10 mL) was added 2-bromoaniline (0.891 g) and pyridine (1.38 mL) and the mixture heated at 40° C. for 4 hours. The mixture was treated with ethyl acetate and brine and the organic layer was washed with 5% aqueous citric acid and aqueous sodium bicarbonate, dried over magnesium sulfate, and concentrated to afford the title compound.

1. washthe organic layer was washed with 5% aqueous citric acid and aqueous sodium bicarbonate
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated