HCID 66649236, compound → HCID 66649563, compound

HRID 419787Notes

Reaction equation

HRID 419787 reaction equation
C([O:9][C@@H:10]1[C@H:14]([O:15]C(=O)C2C=CC=CC=2)[C@@H:13]([CH2:24][O:25]C(=O)C2C=CC=CC=2)[O:12][C@H:11]1[N:34]1[C:43](=[O:44])[C:42]2[NH:41][CH:40]=[N:39][C:38]=2[NH:37][C:35]1=[O:36])(=O)C1C=CC=CC=1>N>[C@@H:11]1([N:34]2[C:43](=[O:44])[C:42]3[NH:41][CH:40]=[N:39][C:38]=3[NH:37][C:35]2=[O:36])[O:12][C@H:13]([CH2:24][OH:25])[C@@H:14]([OH:15])[C@H:10]1[OH:9]

Participants

3

Reactant 1

HCID 66649236HCID 66649236, compound

Product 1

HCID 66649563HCID 66649563, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

A solution of compound 51 (500 mg, 0.84 mmol) in saturated methanolic ammonia (10 mL) was stirred at room temperature for 24 hr, concentrated to dryness, washed with EtOAc several times, and dried to give 52 (200 mg, 84%) as a white solid.

Workup

  1. concentrationconcentrated to dryness
  2. washwashed with EtOAc several times
  3. customdried

Sources & evidence

ORD record
ord-5511c2c2490f4d8a902387371d77f908
Source dataset
uspto-grants-2012_01
Patent number
US08093380B2

Reaction notes

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