p-Toluenesulfonic acid → N-methylhex-5-en-1-amine 4-methylbenzenesulfonate

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Reaction Steps

At room temperature, compound 31a (71.88 g, 1 eq.) and p-toluene sulfonic acid (74.4 g, 1.2 eq.) were dissolved in MeOH (640 mL). The reaction mixture was refluxed for 7 days. The solvent was then removed under vacuum, and the residue was recrystallized in acetone. The product was isolated by filtration, dried over P2O5 to give compound 32a as a white powder in 76% yield.

Provenance & Evidence