反应详情

At room temperature, compound 31a (71.88 g, 1 eq.) and p-toluene sulfonic acid (74.4 g, 1.2 eq.) were dissolved in MeOH (640 mL). The reaction mixture was refluxed for 7 days. The solvent was then removed under vacuum, and the residue was recrystallized in acetone. The product was isolated by filtration, dried over P2O5 to give compound 32a as a white powder in 76% yield.

1. temperatureThe reaction mixture was refluxed for 7 days
2. customThe solvent was then removed under vacuum
3. customthe residue was recrystallized in acetone
4. customThe product was isolated by filtration
5. dry with materialdried over P2O5