2-Chlorophenylboronic acid → 5-Bromo-2-(2-chlorophenyl)pyrimidine

HRID 42008Notes

Reaction equation

HRID 42008 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5](I)=[N:6][CH:7]=1.[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1B(O)O>>[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[Cl:9])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 70066515-Bromo-2-iodopyrimidine

Product 1

HCID 497587025-Bromo-2-(2-chlorophenyl)pyrimidineYield 69%

Procedure

Obtained (0.400 g, yield 69%) following the procedure described in Intermediate 21, starting with 5-bromo-2-iodopyrimidine (2.14 mmol, 0.61 g), 2-chlorophenylboronic acid (2.37 mmol, 0.37 g).

Workup

  1. customObtained (0.400 g, yield 69%)

Sources & evidence

ORD record
ord-190b9fcfb21842519188326b069865c5
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Reaction notes

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