HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420081Generated: October 27, 2026
3-(Trifluoromethyl)pyrazole → 4,8-dichloro-7-methoxy-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)quinoline
https://huagongshe.com/reaction/420081
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(Trifluoromethyl)pyrazole | HCID 1807034 | — |
| Reactant | 2,4,8-Trichloro-7-methoxyquinoline | HCID 2794516 | — |
| Product | 4,8-dichloro-7-methoxy-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)quinoline | HCID 56605213 | 51% |
Reaction Steps
A mixture of compound 45d (5 g, 19 mmol) and 3-trifluoromethylpyrazole 86a (7.76 g, 57 mmol) was heated at 120° C. for 4-6 hrs and the reaction was followed by LCMS and TLC. The reaction mixture was purified by silica gel column (mono and dipyrazole were separated) using DCM and heptane as mobile phase to yield compound 119b (3.5 g) in 51% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093379B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-c38cac5e0432456aac828bda7a786016 |
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| Source note | uspto-grants-2012_01 |
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