HCID 66649387, compound → HCID 24966443, compound

HRID 420131Notes

Reaction equation

[CH:1]1([N:4]2[C:12]3[C:7](=[C:8]([O:16][CH2:17][CH3:18])[CH:9]=[C:10]([C:13]([OH:15])=O)[CH:11]=3)[C:6]([CH3:19])=[CH:5]2)[CH2:3][CH2:2]1.Cl.Cl.[O:22]=[C:23]1[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([C:38]3[CH:43]=[CH:42][N:41]=[C:40]([C:44]([O:46]C)=[O:45])[CH:39]=3)[CH:36]=2)[O:31][C:25]2([CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH2:24]1>>[CH:1]1([N:4]2[C:12]3[C:7](=[C:8]([O:16][CH2:17][CH3:18])[CH:9]=[C:10]([C:13]([N:28]4[CH2:29][CH2:30][C:25]5([CH2:24][C:23](=[O:22])[C:37]6[C:32](=[CH:33][CH:34]=[C:35]([C:38]7[CH:43]=[CH:42][N:41]=[C:40]([C:44]([OH:46])=[O:45])[CH:39]=7)[CH:36]=6)[O:31]5)[CH2:26][CH2:27]4)=[O:15])[CH:11]=3)[C:6]([CH3:19])=[CH:5]2)[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 66649387HCID 66649387, compound

HCID 66649738HCID 66649738, compound

Product 1

HCID 24966443HCID 24966443, compound

Procedure

In the same manner as described in Example 42 except using 1-cyclopropyl-4-ethoxy-3-methyl-1H-indole-6-carboxylic acid and methyl 4-(4-oxospiro[chroman-2,4′-piperidin]-6-yl)pyridine-2-carboxylate dihydrochloride, the title compound was obtained as a colorless amorphous substance. 1H-NMR (400 MHz, DMSO-d6) δ: 8.72 (1H, d, J=4.9 Hz), 8.25 (1H, d, J=1.5 Hz), 8.15-8.11 (2H, m), 7.94 (1H, dd, J=6.0, 2.0 Hz), 7.28 (1H, dd, J=6.0, 2.9 Hz), 7.12 (1H, d, J=1.0 Hz), 6.99 (1H, d, J=1.0 Hz), 6.48 (1H, s), 4.45-4.10 (1H, br m), 4.08 (2H, q, J=6.8 Hz), 3.67-3.19 (4H, m), 2.97 (2H, s), 2.32 (3H, s), 2.12-1.74 (4H, br m), 1.37 (3H, t, J=6.8 Hz), 1.03-0.98 (2H, m), 0.88-0.85 (2H, m); MS [M+H]+=580.

Sources & evidence

ORD record: ord-e9bd99eb9e654096a47c66e362d1fef3
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08093389B2

Reaction notes

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