HCID 66649387, compound → HCID 24966443, compound

Participants

Reaction Steps

In the same manner as described in Example 42 except using 1-cyclopropyl-4-ethoxy-3-methyl-1H-indole-6-carboxylic acid and methyl 4-(4-oxospiro[chroman-2,4′-piperidin]-6-yl)pyridine-2-carboxylate dihydrochloride, the title compound was obtained as a colorless amorphous substance. 1H-NMR (400 MHz, DMSO-d6) δ: 8.72 (1H, d, J=4.9 Hz), 8.25 (1H, d, J=1.5 Hz), 8.15-8.11 (2H, m), 7.94 (1H, dd, J=6.0, 2.0 Hz), 7.28 (1H, dd, J=6.0, 2.9 Hz), 7.12 (1H, d, J=1.0 Hz), 6.99 (1H, d, J=1.0 Hz), 6.48 (1H, s), 4.45-4.10 (1H, br m), 4.08 (2H, q, J=6.8 Hz), 3.67-3.19 (4H, m), 2.97 (2H, s), 2.32 (3H, s), 2.12-1.74 (4H, br m), 1.37 (3H, t, J=6.8 Hz), 1.03-0.98 (2H, m), 0.88-0.85 (2H, m); MS [M+H]+=580.

Provenance & Evidence