Potassium Carbonate → ethyl 1-cyclopropyl-4-hydroxy-1H-indole-6-carboxylate

Participants

Reaction Steps

To a solution of 72.33 g of ethyl 4-acetoxy-1-cyclopropyl-1H-indole-6-carboxylate in 360 ml of EtOH placed in a 2 L flask was added 69.58 g of K2CO3 and the mixture was stirred at room temperature for 4 hrs. EtOH was evaporated and the concentrate was diluted with EtOAc. The mixture was washed with water and saturated brine, dried over Na2SO4, and concentrated. The residue was triturated with toluene and n-hexane to give 49.78 g of ethyl 1-cyclopropyl-4-hydroxy-1H-indole-6-carboxylate as a pale tan solid.

Provenance & Evidence