反应详情

To a solution of 72.33 g of ethyl 4-acetoxy-1-cyclopropyl-1H-indole-6-carboxylate in 360 ml of EtOH placed in a 2 L flask was added 69.58 g of K2CO3 and the mixture was stirred at room temperature for 4 hrs. EtOH was evaporated and the concentrate was diluted with EtOAc. The mixture was washed with water and saturated brine, dried over Na2SO4, and concentrated. The residue was triturated with toluene and n-hexane to give 49.78 g of ethyl 1-cyclopropyl-4-hydroxy-1H-indole-6-carboxylate as a pale tan solid.

1. customEtOH was evaporated
2. additionthe concentrate was diluted with EtOAc
3. washThe mixture was washed with water and saturated brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customThe residue was triturated with toluene and n-hexane