HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420143Generated: October 30, 2026
Hydrochloric Acid → 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylic acid
https://huagongshe.com/reaction/420143
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | ethyl 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylate | HCID 66649481 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylic acid | HCID 66649403 | 102.1% |
Reaction Steps
35 ml of 5N NaOHaq was added to a solution of 15.15 g of ethyl 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylate in MeOH and the mixture was stirred at 60° C. for 8 hrs. The mixture was cooled to 0° C. and 35 ml of 5N HCl was added thereto. The precipitate was filtered and dried in vacuo to give 13.8 g of 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylic acid as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093389B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-2658d04a79664bfc89460908213bc932 |
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| Source note | uspto-grants-2012_01 |
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