反应详情

温度

60 °C

To a stirred solution of 1.03 g of ethyl-3-chloro-1-cyclopropyl-4-(methyloxy)-1H-indole-6-carboxylate in 15 ml of MeOH and 10 ml of THF was added 2 ml of 5N NaOHaq and the mixture was stirred at 60° C. for 9 hrs. After evaporation of MeOH and THF, the mixture was diluted with water and 2 ml of 5N HClaq was added thereto. The precipitate was collected by filtration and dried in vacuo to give 798 mg of 3-chloro-1-cyclopropyl-4-(methyloxy)-1H-indole-6-carboxylic acid as a colorless solid.

1. customAfter evaporation of MeOH and THF
2. additionthe mixture was diluted with water and 2 ml of 5N HClaq
3. additionwas added
4. filtrationThe precipitate was collected by filtration
5. customdried in vacuo