反应详情

60 mL of MeOH, 7.97 g of N-Boc-piperidin-4-one, and 3.34 mL of pyrrolidine were added to 8.60 g of 5-bromo-2-hydroxyacetophenone put in a 200-mL flask equipped with a condenser, and the mixture was overnight heated under reflux. The reaction mixture was cooled to room temperature, and concentrated. The residue was purified through silica gel column chromatography (eluted with n-hexane/EtOAc=6/1) to obtain the intended compound as a pale yellow solid.

1. customput in a 200-mL flask
2. customequipped with a condenser
3. temperatureheated
4. temperatureunder reflux
5. concentrationconcentrated
6. customThe residue was purified through silica gel column chromatography (eluted with n-hexane/EtOAc=6/1)