Hydrochloric Acid → HCID 66649349, compound

Participants

Reaction Steps

5-(1′-tert-butoxycarbonyl-4-oxospiro[chroman-2,4′-piperidin]-6-yl)nicotinic acid methyl ester (22.0 g, 48.6 mmol) was suspended in MeOH (110 mL) and 4 N HCl in dioxane (220 mL) was added thereto, and stirred at room temperature for 14 hours. The solvents were removed in vacuo and the resulting solid was washed with MeOH/Et2O (50 mL/200 mL) to obtain the intended compound as a colorless solid.

Provenance & Evidence