Hydrochloric Acid → HCID 66649349, compound

HRID 420159Notes

Reaction equation

HRID 420159 reaction equation
[CH3:1][O:2][C:3](=[O:33])[C:4]1[CH:9]=[C:8]([C:10]2[CH:11]=[C:12]3[C:29](=[CH:30][CH:31]=2)[O:28][C:15]2([CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH2:14][C:13]3=[O:32])[CH:7]=[N:6][CH:5]=1.[ClH:34]>CO.O1CCOCC1>[ClH:34].[ClH:34].[CH3:1][O:2][C:3](=[O:33])[C:4]1[CH:9]=[C:8]([C:10]2[CH:11]=[C:12]3[C:29](=[CH:30][CH:31]=2)[O:28][C:15]2([CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[CH2:14][C:13]3=[O:32])[CH:7]=[N:6][CH:5]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 56971665HCID 56971665, compound

Product 1

HCID 66649349HCID 66649349, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

5-(1′-tert-butoxycarbonyl-4-oxospiro[chroman-2,4′-piperidin]-6-yl)nicotinic acid methyl ester (22.0 g, 48.6 mmol) was suspended in MeOH (110 mL) and 4 N HCl in dioxane (220 mL) was added thereto, and stirred at room temperature for 14 hours. The solvents were removed in vacuo and the resulting solid was washed with MeOH/Et2O (50 mL/200 mL) to obtain the intended compound as a colorless solid.

Workup

  1. customThe solvents were removed in vacuo
  2. washthe resulting solid was washed with MeOH/Et2O (50 mL/200 mL)

Sources & evidence

ORD record
ord-4a647bbf8e224f7baabdf9a1a72227fd
Source dataset
uspto-grants-2012_01
Patent number
US08093389B2

Reaction notes

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