反应详情

温度

-30 °C

Under nitrogen atmosphere, 7.1 mL (50.6 mmol, 3 eq) of diisopropylamine was added to 200 mL of THF. At −73˜−68° C., 31.6 mL (50.6 mmol, 3 eq) of a 1.6 M solution of n-butyllithium in hexane was added dropwise over 10 minutes. After stirred at 75˜−68° C. for 10 minutes, 5 mL of ethyl acetate was added dropwise at −75˜−70° C. over 5 minutes. After stirred at −75˜−70° C. for 30 minutes, a solution of 8.8 g (16.8 mmol) of N-methyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide in 22 mL of THF was added dropwise at −75˜−65° C. over 5 minutes. After stirred at −75˜−65° C. for 30 minutes, the mixture was warmed to −30° C. After stirred for 5 minutes, 50 mL of an aqueous saturated ammonium chloride solution was added dropwise at −70˜−40° C., and a temperature was rised to room temperature. After the layers were separated, the aqueous layer was re-extracted with 100 mL of ethyl acetate. The organic layers were combined, and washed with 50 mL of an aqueous saturated sodium chloride solution. After concentration under reduced pressure, 100 mL of n-heptane was added to the concentration residue, followed by stirring at room temperature for 30 minutes. Crystals were filtered, and washed with 50 mL of n-heptane. Vacuum drying (50° C.) to a constant weight afforded 9.82 g of ethyl 3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate (yield 96%).

1. stirringAfter stirred at −75˜−70° C. for 30 minutes
2. stirringAfter stirred at −75˜−65° C. for 30 minutes
3. stirringAfter stirred for 5 minutes
4. customwas rised to room temperature
5. customAfter the layers were separated
6. extractionthe aqueous layer was re-extracted with 100 mL of ethyl acetate
7. washwashed with 50 mL of an aqueous saturated sodium chloride solution
8. concentrationAfter concentration under reduced pressure, 100 mL of n-heptane
9. additionwas added to the concentration residue
10. stirringby stirring at room temperature for 30 minutes
11. filtrationCrystals were filtered
12. washwashed with 50 mL of n-heptane
13. customVacuum drying (50° C.) to a constant weight