HCID 57586564, compound → HCID 25191878, compound

HRID 420352Notes

Reaction equation

HRID 420352 reaction equation
C([O:3][C:4](=[O:49])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28]3[CH:33]=[CH:32][N:31]=[C:30]([F:34])[CH:29]=3)[CH:25]=[C:24]([C:35]3[CH:40]=[CH:39][N:38]=[C:37]([F:41])[CH:36]=3)[CH:23]=2)[C:10]=1[CH2:42][CH2:43][C:44]([O:46]CC)=[O:45])C>[OH-].[Na+]>[F:41][C:37]1[CH:36]=[C:35]([C:24]2[CH:23]=[C:22]([CH:27]=[C:26]([C:28]3[CH:33]=[CH:32][N:31]=[C:30]([F:34])[CH:29]=3)[CH:25]=2)[O:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:11]2[C:10]([CH2:42][CH2:43][C:44]([OH:46])=[O:45])=[C:9]([CH:14]=[CH:13][CH:12]=2)[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:49])=[O:3])[CH:40]=[CH:39][N:38]=1

Participants

3

Reactant 1

HCID 57586564HCID 57586564, compound

Product 1

HCID 25191878HCID 25191878, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A similar procedure as described in Example 1, step 3 was used, starting from 4-[3-{6-[3,5-bis-(2-fluoro-pyridin-4-yl)-phenoxy]-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (220 mg, 0.32 mmol) and 1.0 N aqueous NaOH (10 mL) to afford 4-[3-{6-[3,5-bis-(2-fluoro-pyridin-4-yl)-phenoxy]-hexyl}-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (110 mg, 56%) as an amorphous white solid: ES(+)-HRMS m/e calculated for C35H36F2N2O6 (M+H)+ 619.2614, found 619.2615.

Sources & evidence

ORD record
ord-d388c8900dde479aa2b8f81c86d812b3
Source dataset
uspto-grants-2012_01
Patent number
US08093385B2

Reaction notes

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