Sodium Hydroxide → HCID 57586519, compound

HRID 420380Notes

Reaction equation

C([O:3][C:4](=[O:43])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:23]=[C:24]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[CH:30]=3)[CH:25]=[C:26]([I:28])[CH:27]=2)[C:10]=1[CH2:36][CH2:37][C:38]([O:40]CC)=[O:39])C.[OH-].[Na+]>>[C:38]([CH2:37][CH2:36][C:10]1[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:23]=[C:24]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[CH:30]=3)[CH:25]=[C:26]([I:28])[CH:27]=2)=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:43])=[O:3])([OH:40])=[O:39]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 57586479HCID 57586479, compound

Product 1

HCID 57586519HCID 57586519, compoundYield 91%

Procedure

A similar procedure as described in Example 12, step 9 was used, starting from 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3′-fluoro-5-iodo-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid ethyl ester (2.23 g, 3.17 mmol) and aqueous 1.0 N sodium hydroxide (31.65 mL) to obtain 4-{2-(2-carboxy-ethyl)-3-[6-(3′-fluoro-5-iodo-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid (1.86 g, 91%) as a light yellow oil: ES(+)-HRMS m/e calculated for C31H34FIO6 (M+Na)+ 671.1276, found 671.1271.

Sources & evidence

ORD record: ord-71edd9973cd14ed2b8c190829c6ed0f9
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08093385B2

Reaction notes

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