Sodium Cyanide → HCID 54741066, compound

HRID 420448Notes

Reaction equation

[C:1]([C:3]1[N:4]=[CH:5][C:6]2[C:12]([OH:13])=[C:11]([C:14]([NH:16][CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])=[O:15])[C:10](=[O:25])[N:9]([CH3:26])[C:7]=2[N:8]=1)#[N:2].OC1C2C=NC(S(C)(=O)=O)=NC=2N(C)C(=O)C=1C(NCC(OC(C)(C)C)=O)=O.[C-]#N.[Na+]>>[C:1]([C:3]1[N:4]=[CH:5][C:6]2[C:12]([OH:13])=[C:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[C:10](=[O:25])[N:9]([CH3:26])[C:7]=2[N:8]=1)#[N:2]

Participants

Reactant 3

HCID 8929Sodium Cyanide

HCID 66658633HCID 66658633, compound

HCID 66658653HCID 66658653, compound

Product 1

HCID 54741066HCID 54741066, compound

Procedure

tert-Butyl 2-(2-cyano-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)acetate. The title compound is prepared by reaction of tert-butyl 2-(5-hydroxy-8-methyl-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)acetate with sodium cyanide according to the procedure described in Bioorg. Med. Chem. Lett., 17, 6206 (2007).

Sources & evidence

ORD record: ord-0fda0e15ffdd461f8a26c7d44b6ec357
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08097620B2

Reaction notes

Loading…