Ammonia → HCID 54741072, compound

HRID 420449Notes

Reaction equation

HRID 420449 reaction equation
[OH:1][C:2]1[C:11]2[CH:10]=[C:9]([O:12][CH3:13])[N:8]=[N:7][C:6]=2[N:5]([CH3:14])[C:4](=[O:15])[C:3]=1[C:16]([O:18]C)=O.ClC1N=NC2N(C)C(=O)[C:29]([C:32]([O:34]C)=[O:33])=C(O)C=2C=1.C[O-].[Na+].[NH3:41]>CO>[OH:1][C:2]1[C:11]2[CH:10]=[C:9]([O:12][CH3:13])[N:8]=[N:7][C:6]=2[N:5]([CH3:14])[C:4](=[O:15])[C:3]=1[C:16]([NH:41][CH2:29][C:32]([OH:34])=[O:33])=[O:18]

Participants

6

Reactant 4

HCID 222AmmoniaHCID 10942334Sodium MethoxideHCID 66658610HCID 66658610, compoundHCID 86629415HCID 86629415, compound2×

Product 1

HCID 54741072HCID 54741072, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 5-hydroxy-3-methoxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate. The title compound is prepared by reaction of methyl 3-chloro-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate with sodium methoxide according the procedure described in Bioorg. Med. Chem. Lett., 17, 6206 (2007). Alternatively, the title compound is prepared by reaction of methyl 3-chloro-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate with ammonia in MeOH solution according to Method 8(a).

Sources & evidence

ORD record
ord-6414f0dd51f440089fc08bb5a79e0a4f
Source dataset
uspto-grants-2012_01
Patent number
US08097620B2

Reaction notes

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