HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 54741072, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 66658610 | HCID 66658610 | — |
| Reactant | HCID 86629415 | HCID 86629415 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 54741072 | HCID 54741072 | — |
Reaction Steps
Methyl 5-hydroxy-3-methoxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate. The title compound is prepared by reaction of methyl 3-chloro-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate with sodium methoxide according the procedure described in Bioorg. Med. Chem. Lett., 17, 6206 (2007). Alternatively, the title compound is prepared by reaction of methyl 3-chloro-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate with ammonia in MeOH solution according to Method 8(a).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097620B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-6414f0dd51f440089fc08bb5a79e0a4f |
| Source note | uspto-grants-2012_01 |