Piperidine → HCID 54741073, compound

HRID 420451Notes

Reaction equation

[OH:1][C:2]1[C:11]2[CH:10]=[C:9]([N:12]3[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[N:8]=[N:7][C:6]=2[N:5]([CH3:18])[C:4](=[O:19])[C:3]=1[C:20](OC)=[O:21].ClC1N=NC2N(C)C(=O)[C:33]([C:36]([O:38]C)=[O:37])=C(O)C=2C=1.[NH:42]1CCCCC1>>[OH:1][C:2]1[C:11]2[CH:10]=[C:9]([N:12]3[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[N:8]=[N:7][C:6]=2[N:5]([CH3:18])[C:4](=[O:19])[C:3]=1[C:20]([NH:42][CH2:33][C:36]([OH:38])=[O:37])=[O:21]

Participants

Reactant 3

HCID 8082Piperidine2×

HCID 66658647HCID 66658647, compound

HCID 86629415HCID 86629415, compound2×

Product 1

HCID 54741073HCID 54741073, compound

Procedure

Methyl 5-hydroxy-8-methyl-7-oxo-3-(piperidin-1-yl)-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate. The title compound is prepared by reaction of methyl 3-chloro-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate with piperidine according to literature procedures. Alternatively, the title compound is prepared by reaction of methyl 3-chloro-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate with piperidine according to Method 7(a).

Sources & evidence

ORD record: ord-e112f44d2d384bf8b8fbde79e9840147
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08097620B2

Reaction notes

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