3-Chloro-5-fluorobenzoic acid → 3-Cyclopropyl-5-fluorobenzoic acid

HRID 42049Notes

Reaction equation

HRID 42049 reaction equation
N[C:2]1[CH:11]=[CH:10][C:9]([CH:12]2[CH2:14][CH2:13]2)=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].ClC1C=C(C=C([F:25])C=1)C(O)=O>>[CH:12]1([C:9]2[CH:8]=[C:3]([CH:2]=[C:11]([F:25])[CH:10]=2)[C:4]([OH:6])=[O:5])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 27348403-Chloro-5-fluorobenzoic acidHCID 13052309Methyl 2-amino-5-cyclopropylbenzoate

Product 1

HCID 673954473-Cyclopropyl-5-fluorobenzoic acidYield 16%

Procedure

Obtained (16% yield) following the procedure described in intermediate 8 (step A), starting from 3-chloro-5-fluorobenzoic acid.

Workup

  1. customObtained (16% yield)

Sources & evidence

ORD record
ord-d6b4d82d29344b36986829566dff2b6f
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Reaction notes

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