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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42049Generated: October 25, 2026

3-Chloro-5-fluorobenzoic acid → 3-Cyclopropyl-5-fluorobenzoic acid

https://huagongshe.com/reaction/42049

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-5-fluorobenzoic acidHCID 2734840—
ReactantMethyl 2-amino-5-cyclopropylbenzoateHCID 13052309—
Product3-Cyclopropyl-5-fluorobenzoic acidHCID 6739544716%

Reaction Steps

Obtained (16% yield) following the procedure described in intermediate 8 (step A), starting from 3-chloro-5-fluorobenzoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536165B2
Source datasetuspto-grants-2013_09
ORD IDord-d6b4d82d29344b36986829566dff2b6f
Source noteuspto-grants-2013_09