2-(Trifluoromethyl)benzeneboronic acid → 5-Bromo-2-(2-(trifluoromethyl)phenyl)pyrimidine

HRID 42052Notes

Reaction equation

HRID 42052 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5](I)=[N:6][CH:7]=1.[F:9][C:10]([F:21])([F:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1B(O)O>>[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10]([F:21])([F:20])[F:9])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 27343872-(Trifluoromethyl)benzeneboronic acidHCID 70066515-Bromo-2-iodopyrimidine

Product 1

HCID 497586975-Bromo-2-(2-(trifluoromethyl)phenyl)pyrimidineYield 52%

Procedure

Obtained (52% yield) following the procedure described in Intermediate 21, starting with 5-bromo-2-iodopyrimidine and 2-(trifluoromethyl)phenylboronic acid.

Workup

  1. customObtained (52% yield)

Sources & evidence

ORD record
ord-3b57758fd6614679a9a60fa13dd81082
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Reaction notes

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