HCID 67394526, compound → HCID 25186172, compound

HRID 42053Notes

Reaction equation

HRID 42053 reaction equation
[CH:1]1([C:4]2[N:9]=[CH:8][C:7]([NH:10][C:11]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:12]=3[C:13]([O:15]C(C)(C)C)=[O:14])=[CH:6][C:5]=2[CH3:25])[CH2:3][CH2:2]1>C(O)(C(F)(F)F)=O>[CH:1]1([C:4]2[N:9]=[CH:8][C:7]([NH:10][C:11]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:12]=3[C:13]([OH:15])=[O:14])=[CH:6][C:5]=2[CH3:25])[CH2:2][CH2:3]1

Participants

3

Reactant 1

HCID 67394526HCID 67394526, compound

Product 1

HCID 25186172HCID 25186172, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl 2-(6-cyclopropyl-5-methylpyridin-3-ylamino)-5-methylbenzoate (1.52 mmol, 0.514 g) in TFA (5 ml) was stirred at room temperature for 30 minutes. The solvent was reduced under reduced pressure and the crude mixture was purified by reverse phase chromatography using a 30% to 100% (Water-ACN) gradient and affording 0.150 g (35% of yield) of the expected product.

Workup

  1. customthe crude mixture was purified by reverse phase chromatography
  2. customaffording

Sources & evidence

ORD record
ord-124a7bfd93fd4249bf28d64ed234c32c
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Reaction notes

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