反应详情

To a stirred solution of 5-cyclopropyl-2-(5-methyl-6-phenylpyridin-3-ylamino)benzoic acid (0.29 mmol, 0.1 g) in 4 ml of dichloromethane was added mCPBA in portions, at 0° and under argon atmosphere. After the addition the mixture was stirred overnight at room temperature. The solvent was evaporated and the solid residue was triturated with a water/ethyl acetate mixture. The solid was filtered off affording 0.035 g (33% of yield) of the expected product.

1. customat 0°
2. additionAfter the addition the mixture
3. customThe solvent was evaporated
4. customthe solid residue was triturated with a water/ethyl acetate mixture
5. filtrationThe solid was filtered off
6. customaffording