Sodium Hydroxide → HCID 57966727, compound

HRID 420558Notes

Reaction equation

HRID 420558 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16]O)[CH2:11][CH2:10]3)[S:8][C:4]=2[CH:3]=1.[OH-].[Na+].S(Cl)([Cl:24])=O>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][Cl:24])[CH2:11][CH2:10]3)[S:8][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 24386Thionyl ChlorideHCID 579661101-(6-Chloro-2-benzothiazolyl)-4-piperidineethanol

Product 1

HCID 57966727HCID 57966727, compound

Conditions

Temperature
60 °C

Procedure

To 6-chloro-2-[4-(2-hydroxyethyl)piperidine-1-yl]benzothiazole (1.20 g; 4.03 mmol) was added thionyl chloride (10 ml). The mixture was stirred at 60° C. for 1 hour. The reaction solution was poured into ice water. 5N aqueous sodium hydroxide was added thereto to neutralize and the precipitate was collected. The precipitate was washed with diisopropyl ether to give 6-chloro-2-[4-(2-chloroethyl)piperidine-1-yl]benzothiazole as colorless crystal (0.98 g; 77%).

Workup

  1. customthe precipitate was collected
  2. washThe precipitate was washed with diisopropyl ether

Sources & evidence

ORD record
ord-69a8c033b86e4484bfd91560a4ddae27
Source dataset
uspto-grants-2012_01
Patent number
US08097610B2

Reaction notes

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