HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420558Generated: October 30, 2026
Sodium Hydroxide → HCID 57966727, compound
https://huagongshe.com/reaction/420558
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(6-Chloro-2-benzothiazolyl)-4-piperidineethanol | HCID 57966110 | — |
| Product | HCID 57966727 | HCID 57966727 | — |
Reaction Steps
To 6-chloro-2-[4-(2-hydroxyethyl)piperidine-1-yl]benzothiazole (1.20 g; 4.03 mmol) was added thionyl chloride (10 ml). The mixture was stirred at 60° C. for 1 hour. The reaction solution was poured into ice water. 5N aqueous sodium hydroxide was added thereto to neutralize and the precipitate was collected. The precipitate was washed with diisopropyl ether to give 6-chloro-2-[4-(2-chloroethyl)piperidine-1-yl]benzothiazole as colorless crystal (0.98 g; 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08097610B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-69a8c033b86e4484bfd91560a4ddae27 |
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| Source note | uspto-grants-2012_01 |
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