Hydrochloric Acid → HCID 57966060, compound

HRID 420564Notes

Reaction equation

HRID 420564 reaction equation
[Cl:1][C:2]1[CH:30]=[CH:29][C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][O:17][C:18]4[CH:19]=[C:20]([CH:26]=[CH:27][CH:28]=4)[C:21]([O:23]CC)=[O:22])[CH2:11][CH2:10]3)[S:8][C:4]=2[CH:3]=1.[OH-].[Na+].CO.Cl>O>[Cl:1][C:2]1[CH:30]=[CH:29][C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][O:17][C:18]4[CH:19]=[C:20]([CH:26]=[CH:27][CH:28]=4)[C:21]([OH:23])=[O:22])[CH2:11][CH2:10]3)[S:8][C:4]=2[CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 57966360HCID 57966360, compound

Product 1

HCID 57966060HCID 57966060, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of Ethyl 3-{2-[1-(6-chlorobenzothiazole-2-yl)piperidine-4-yl]ethoxy}benzoate (0.30 g; 6.671 mmol), 2N-aqueous sodium hydroxide (1.5 ml) and methanol (3 ml) was stirred at 60° C. for 1 hour. The reaction solution was condensed under reduced pressure. To the residue were added water and 2N aqueous hydrochloric acid to be neutral. The precipitate was collected and washed with water and diisopropyl ether to give 3-{2-[1-(6-chlorobenzothiazole-2-yl)piperidine-4-yl]ethoxy}benzoic acid as colorless crystal (0.26 g; 93%).

Workup

  1. customcondensed under reduced pressure
  2. customThe precipitate was collected
  3. washwashed with water and diisopropyl ether

Sources & evidence

ORD record
ord-693d208e52a240859b07d9f16ebe0860
Source dataset
uspto-grants-2012_01
Patent number
US08097610B2

Reaction notes

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