HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67395129, compound → 2-(5-Fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67395129 | HCID 67395129 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 2-(5-Fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoic acid | HCID 25186450 | — |
Reaction Steps
A solution of tert-butyl 2-(5-fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoate (0.83 mmol, 0.313 g) in TFA (5 ml) was stirred at room temperature for 30 minutes. The solvent was reduced under reduced pressure and the crude mixture was purified by reverse phase chromatography using a 30% to 100% (Water-ACN) gradient and affording 0.119 g (40% of yield) of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536165B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-18a920ce37b24924ac86bc940506d702 |
| Source note | uspto-grants-2013_09 |