Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42058Generated: November 2, 2026

HCID 67395129, compound → 2-(5-Fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoic acid

https://huagongshe.com/reaction/42058

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 67395129HCID 67395129—
SolventTrifluoroacetic acidHCID 6422—
Product2-(5-Fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoic acidHCID 25186450—

Reaction Steps

A solution of tert-butyl 2-(5-fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoate (0.83 mmol, 0.313 g) in TFA (5 ml) was stirred at room temperature for 30 minutes. The solvent was reduced under reduced pressure and the crude mixture was purified by reverse phase chromatography using a 30% to 100% (Water-ACN) gradient and affording 0.119 g (40% of yield) of the expected product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536165B2
Source datasetuspto-grants-2013_09
ORD IDord-18a920ce37b24924ac86bc940506d702
Source noteuspto-grants-2013_09