HCID 67395129, compound → 2-(5-Fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoic acid

HRID 42058Notes

Reaction equation

HRID 42058 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:14][C:15]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:16]=2[C:17]([O:19]C(C)(C)C)=[O:18])[CH:5]=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(O)(C(F)(F)F)=O>[F:1][C:2]1[CH:3]=[C:4]([NH:14][C:15]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:16]=2[C:17]([OH:19])=[O:18])[CH:5]=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 1

HCID 67395129HCID 67395129, compound

Product 1

HCID 251864502-(5-Fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoic acid

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl 2-(5-fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoate (0.83 mmol, 0.313 g) in TFA (5 ml) was stirred at room temperature for 30 minutes. The solvent was reduced under reduced pressure and the crude mixture was purified by reverse phase chromatography using a 30% to 100% (Water-ACN) gradient and affording 0.119 g (40% of yield) of the expected product.

Workup

  1. customthe crude mixture was purified by reverse phase chromatography
  2. customaffording

Sources & evidence

ORD record
ord-18a920ce37b24924ac86bc940506d702
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Reaction notes

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