HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-Benzyl-4-pyrrolidine-1-ylpiperidine-4-yl)ethanol → 2-(4-Pyrrolidine-1-ylpiperidine-4-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-Benzyl-4-pyrrolidine-1-ylpiperidine-4-yl)ethanol | HCID 66658038 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Pyrrolidine-1-ylpiperidine-4-yl)ethanol | HCID 57966207 | 99% |
Reaction Steps
A mixture of 2-(1-benzyl-4-pyrrolidine-1-ylpiperidine-4-yl)ethanol (9.28 g), 10% Pd/C (1.86 g) and methanol (100 mL) was stirred under hydrogen (4 atm) for 3 days. The insoluble material was filtrated and the filtrate was concentrated to give the title compound (6.30 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097610B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-83a0a66d48144ab989e5ffabec341c64 |
| Source note | uspto-grants-2012_01 |