反应详情

A mixture of [3-[2-[1-(5-bromothiazole-2-yl)-4-pyrrolidine-1-ylpiperidine-4-yl]ethoxy]-5-chlorophenyl]acetic acid (60 mg), 3-fluorophenyl boronic acid (32 mg), tetrakis (triphenylphosphine) palladium (13 mg), 1M sodium carbonate (0.55 mL) and dimethylformamide (1 mL) was reacted with a microwave reaction device at 180° C. for 5 minutes. The insoluble material was filtrated. To the filtrate was added formic acid. The solvent was evaporated under reduced pressure and the residue was purified by high performance liquid chromatography to give the title compound (14.4 mg). Yield: 24%.

1. customwas reacted with a microwave reaction device at 180° C. for 5 minutes
2. filtrationThe insoluble material was filtrated
3. additionTo the filtrate was added formic acid
4. customThe solvent was evaporated under reduced pressure
5. customthe residue was purified by high performance liquid chromatography