反应详情

A stirred suspension of benzyl 5-acetyl-4-(4-cyanophenyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyridine-3-carboxylate (7.5 g, 14 mmol) (Example 6A) and 10%. palladium on charcoal (255 mg) in tetrahydrofuran (975 ml) is treated with hydrogen gas at room temperature under atmospheric pressure. After 15 minutes, the reaction is stopped and the solution is filtered and concentrated. The residue is immediately used in the next step without further purification and characterisation.

1. filtrationthe solution is filtered
2. concentrationconcentrated
3. customThe residue is immediately used in the next step without further purification and characterisation