HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-Methyl-2-(6-morpholinopyridin-3-ylamino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 5-Methyl-2-(6-morpholinopyridin-3-ylamino)benzoate tert-butyl ester | HCID 67395098 | — |
| Product | 5-Methyl-2-(6-morpholinopyridin-3-ylamino)benzoic acid | HCID 25186996 | — |
Reaction Steps
A solution of 5-methyl-2-(6-morpholinopyridin-3-ylamino)benzoate tert-butyl ester in TFA (0.6 ml, 7.58 mmol) was stirred at room temperature for 1 hour. The solvent was evaporated and the residue was triturated in diethyl ether. The solid formed was filtered off to afford 0.047 g (73% of yield) of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536165B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-173a0ffe83b349cd963070606fb7fc29 |
| Source note | uspto-grants-2013_09 |