3,3-Dimethylbutanoyl chloride → 8-(3,3-Dimethylbutanoyl)-2-(4-(2,2,2-trifluoroethyl)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione

HRID 420661Notes

Reaction equation

HRID 420661 reaction equation
[F:1][C:2]([F:23])([F:22])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][C:12]3([CH2:19][CH2:18][NH:17][C:16](=[O:20])[CH2:15]3)[C:11]2=[O:21])=[CH:6][CH:5]=1.[CH3:24][C:25]([CH3:31])([CH3:30])[CH2:26][C:27](Cl)=[O:28]>>[CH3:24][C:25]([CH3:31])([CH3:30])[CH2:26][C:27]([N:17]1[CH2:18][CH2:19][C:12]2([C:11](=[O:21])[N:10]([C:7]3[CH:8]=[CH:9][C:4]([CH2:3][C:2]([F:1])([F:22])[F:23])=[CH:5][CH:6]=3)[CH2:14][CH2:13]2)[CH2:15][C:16]1=[O:20])=[O:28]

Participants

3

Reactant 2

HCID 815143,3-Dimethylbutanoyl chlorideHCID 584784152-(4-(2,2,2-Trifluoroethyl)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione2×

Product 1

HCID 534826878-(3,3-Dimethylbutanoyl)-2-(4-(2,2,2-trifluoroethyl)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione

Procedure

This material was prepared as a white solid in analogy to example 3) from 2-(4-(2,2,2-trifluoroethyl)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione, product of example 10 step A), and 3,3-dimethyl-butyryl chloride. MS (ESI): 425.2 (MH+).

Sources & evidence

ORD record
ord-22dff49742fb4fdd8d744606acc682ff
Source dataset
uspto-grants-2012_01
Patent number
US08097634B2

Reaction notes

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