3,3-Dimethylbutanoyl chloride → 8-(3,3-Dimethylbutanoyl)-2-(4-(2,2,2-trifluoroethoxy)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione
Reaction equation
[F:1][C:2]([F:24])([F:23])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][C:13]3([CH2:20][CH2:19][NH:18][C:17](=[O:21])[CH2:16]3)[C:12]2=[O:22])=[CH:7][CH:6]=1.[CH3:25][C:26]([CH3:32])([CH3:31])[CH2:27][C:28](Cl)=[O:29]>>[CH3:25][C:26]([CH3:32])([CH3:31])[CH2:27][C:28]([N:18]1[CH2:19][CH2:20][C:13]2([C:12](=[O:22])[N:11]([C:8]3[CH:9]=[CH:10][C:5]([O:4][CH2:3][C:2]([F:1])([F:23])[F:24])=[CH:6][CH:7]=3)[CH2:15][CH2:14]2)[CH2:16][C:17]1=[O:21])=[O:29]Participants
3
Procedure
This material was prepared as a white solid in analogy to example 3) from 2-(4-(2,2,2-trifluoroethoxy)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione and 3,3-dimethyl-butyryl chloride. MS (ESI): 441.19 (MH+).
Sources & evidence
- ORD record
- ord-f5781d0a6be14dc884170163dc14edb0
- Source dataset
- uspto-grants-2012_01
- Patent number
- US08097634B2
Reaction notes
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