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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420663Generated: October 26, 2026

3,3-Dimethylbutanoyl chloride → 8-(3,3-Dimethylbutanoyl)-2-(4-(2,2,2-trifluoroethoxy)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione

https://huagongshe.com/reaction/420663

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,3-Dimethylbutanoyl chlorideHCID 81514—
Reactant2-(4-(2,2,2-Trifluoroethoxy)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dioneHCID 58478410—
Product8-(3,3-Dimethylbutanoyl)-2-(4-(2,2,2-trifluoroethoxy)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dioneHCID 53482742—

Reaction Steps

This material was prepared as a white solid in analogy to example 3) from 2-(4-(2,2,2-trifluoroethoxy)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione and 3,3-dimethyl-butyryl chloride. MS (ESI): 441.19 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08097634B2
Source datasetuspto-grants-2012_01
ORD IDord-f5781d0a6be14dc884170163dc14edb0
Source noteuspto-grants-2012_01