HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 3-(Bromomethyl)-6-(trifluoromethyl)pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 3-Methyl-6-(trifluoromethyl)pyridazine | HCID 20691950 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 3-(Bromomethyl)-6-(trifluoromethyl)pyridazine | HCID 58579404 | 14% |
Reaction Steps
A mixture of 3-methyl-6-(trifluoromethyl)pyridazine (70 mg), N-bromosuccinimide (84 mg), azobisisobutyronitrile (14.1 mg), and CCl4 (3 ml) was heated under reflux for 2 days. The solvent was evaporated to dryness under vacuum. The residue obtained was purified by chromatography column on silica gel (AIT, Flashsmart BP-SUP, 20-40 μm) using a mixture of EtOAc/hexane as eluent to give 14 mg (14%) of the title compound along with 15.3 mg (11%) of the dibrominated derivative.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097628B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-88f16330730444bf947360ffe88e8a03 |
| Source note | uspto-grants-2012_01 |