反应详情

A mixture of 3-methyl-6-(trifluoromethyl)pyridazine (70 mg), N-bromosuccinimide (84 mg), azobisisobutyronitrile (14.1 mg), and CCl4 (3 ml) was heated under reflux for 2 days. The solvent was evaporated to dryness under vacuum. The residue obtained was purified by chromatography column on silica gel (AIT, Flashsmart BP-SUP, 20-40 μm) using a mixture of EtOAc/hexane as eluent to give 14 mg (14%) of the title compound along with 15.3 mg (11%) of the dibrominated derivative.

1. temperaturewas heated
2. temperatureunder reflux for 2 days
3. customThe solvent was evaporated to dryness under vacuum
4. customThe residue obtained
5. customwas purified by chromatography column on silica gel (AIT, Flashsmart BP-SUP, 20-40 μm)
6. additiona mixture of EtOAc/hexane as eluent