反应详情

To a solution of (5,6-dichloro-3-pyridinyl)methanol (200 mg) in DCM, molecular sieves (3 Å) (55 mg) and 4-methyl-morpholine-N-oxide (198 mg) was added and stirred at room temperature for 10 minutes. Then tetra-n-propylammonium perruthenate (VII) (38 mg) was added and stirred overnight. The reaction mixture was filtered and the solvent was evaporated to dryness under vacuum. The residue obtained was purified by chromatography column on silica gel using a mixture of EtOAc/hexane as eluent to give 44 mg (22%) of the title compound.

1. stirringstirred overnight
2. filtrationThe reaction mixture was filtered
3. customthe solvent was evaporated to dryness under vacuum
4. customThe residue obtained
5. customwas purified by chromatography column on silica gel using
6. additiona mixture of EtOAc/hexane as eluent