反应详情

温度

40 °C

To a solution of [5-methyl-6-(trifluoromethyl)-3-pyridinyl]methanol (152 mg, 0.795 mmol) in DCM (10 mL) was added CrO2 (Magtrieve) (1336 mg, 15.90 mmol). The suspension was heated at 40° C. in a pressure tube overnight. The suspension was filtered over nylon membrane 0.45 μm and it was rinsed with DCM. The filtrate was evaporated to afford 120 mg (80%) of title compound pure enough to be used in the next step.

1. filtrationThe suspension was filtered over nylon membrane 0.45 μm and it
2. washwas rinsed with DCM
3. customThe filtrate was evaporated