3-Pyridinemethanol, 5-methyl-6-(trifluoromethyl)- → 3-Methyl-2-(trifluoromethyl)pyridine-5-carbaldehyde
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:12][OH:13])[CH:5]=[N:6][C:7]=1[C:8]([F:11])([F:10])[F:9]>C(Cl)Cl>[CH3:1][C:2]1[CH:3]=[C:4]([CH:12]=[O:13])[CH:5]=[N:6][C:7]=1[C:8]([F:11])([F:9])[F:10]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 40 °C
Procedure
To a solution of [5-methyl-6-(trifluoromethyl)-3-pyridinyl]methanol (152 mg, 0.795 mmol) in DCM (10 mL) was added CrO2 (Magtrieve) (1336 mg, 15.90 mmol). The suspension was heated at 40° C. in a pressure tube overnight. The suspension was filtered over nylon membrane 0.45 μm and it was rinsed with DCM. The filtrate was evaporated to afford 120 mg (80%) of title compound pure enough to be used in the next step.
Workup
- filtrationThe suspension was filtered over nylon membrane 0.45 μm and it
- washwas rinsed with DCM
- customThe filtrate was evaporated
Sources & evidence
- ORD record
- ord-064163d9d65e4efbb451267143eb57f4
- Source dataset
- uspto-grants-2012_01
- Patent number
- US08097628B2
Reaction notes
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