3-Pyridinemethanol, 5-methyl-6-(trifluoromethyl)- → 3-Methyl-2-(trifluoromethyl)pyridine-5-carbaldehyde

Participants

Reaction Conditions

Reaction Steps

To a solution of [5-methyl-6-(trifluoromethyl)-3-pyridinyl]methanol (152 mg, 0.795 mmol) in DCM (10 mL) was added CrO2 (Magtrieve) (1336 mg, 15.90 mmol). The suspension was heated at 40° C. in a pressure tube overnight. The suspension was filtered over nylon membrane 0.45 μm and it was rinsed with DCM. The filtrate was evaporated to afford 120 mg (80%) of title compound pure enough to be used in the next step.

Provenance & Evidence