反应详情

(3-Oxo-cyclohexyl)-acetic acid methyl ester (240 mg, 1.39 mmol) was dissolved in 5 ml THF and 5 ml ethanol and cooled to 0-5° C. Sodium borohydride (79 mg, 2.09 mmol) was added and the reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was quenched with saturated NaHCO3-solution and extracted three times with ethyl acetate. The organic extracts were washed with brine, dried with sodium sulfate, filtered and evaporated. The crude product (240 mg, 100%) was obtained as a light yellow oil and used without any further purification for the next step.

1. customThe reaction mixture was quenched with saturated NaHCO3-solution
2. extractionextracted three times with ethyl acetate
3. washThe organic extracts were washed with brine
4. dry with materialdried with sodium sulfate
5. filtrationfiltered
6. customevaporated