反应详情

HCl (6.0 mL, 4 M solution in dioxane, 24.03 mmol) was dropwise added to a suspension of (2S)-methyl-[5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amine (2.16 g, 8.01 mmol) in Et2O (10 mL). The reaction mixture was stirred at room temperature for 2.5 h and then the solvent was concentrated off. The resulting solid was suspended in Et2O (25 mL) and concentrated, in order to remove excess of HCl. This operation was done for three times, to give 2.42 g of the title product (Rf=0.3 (AcOEt/MeOH/Et3N 20:3:2), white solid, 99% yield).

1. concentrationthe solvent was concentrated off
2. concentrationconcentrated, in order
3. customto remove excess of HCl