反应详情

A solution of (2S)-benzyl-[5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amine (0.287 g, 0.832 mmol) in THF (4 mL) was added to Pd/C (0.10 g, 10% weight of Pd on activated carbon), and MeOH (10 mL) was added to the suspension. The reaction mixture was stirred under H2 (g) atmosphere (balloon) for 21 h. It was filtered through Celite washing with AcOEt (2×10 mL), the solvent was concentrated off and the crude was purified by flash chromatography on silica gel (CH2Cl2/MeOH/NH4OH 95:5:1), to yield 0.178 g of the title product (Rf=0.2 (AcOEt/MeOH/Et3N 20:3:2), pale yellow colored oil, 84% yield).

1. additionwas added to the suspension
2. filtrationIt was filtered through Celite
3. washwashing with AcOEt (2×10 mL)
4. concentrationthe solvent was concentrated off
5. customthe crude was purified by flash chromatography on silica gel (CH2Cl2/MeOH/NH4OH 95:5:1)