反应详情

General Procedure B. To a solution of (1-benzyl-2-isopropyl-5-(methoxymethoxy)-1H-indol-3-yl)methanol (Compound 3, 120 mg, 0.35 mmol) in CH2Cl2 was added 4-methylmorpholine N-oxide (NMO, 129 mg, 1.1 mmol) and tetrapropylammonium perruthenate (TPAP, 14 mg, 0.040 mmol). The reaction was stirred at room temperature for 2.5 h, and the product was purified by flash chromatography on silica gel eluting with 20% EtOAc-hexanes to yield 1-benzyl-2-isopropyl-5-(methoxymethoxy)-1H-indole-3-carboxaldehyde (Compound 4) as an off-white solid.

1. customthe product was purified by flash chromatography on silica gel eluting with 20% EtOAc-hexanes